Special Price for Noscapine Hydrochloride Hydrate - Gemcitabine Hydrochloride CAS 122111-03-9 API USP Standard High Purity – Ruifu

Short Description:


Product Detail

Related Products

Product Tags

Related Video

Feedback (2)

Our development depends on the advanced equipment, excellent talents and continuously strengthened technology forces for Molecular Formula C7H4ClFO, 154361-50-9, (2S)-1-(Chloroacetyl)-2-pyrrolidinecarbonitrile, Welcome to visit our company and factory. Please feel free to get in touch with us if you need any further assistance.
Special Price for Noscapine Hydrochloride Hydrate - Gemcitabine Hydrochloride CAS 122111-03-9 API USP Standard High Purity – Ruifu Detail:

Manufacturer with High Purity and Stable Quality
Chemical Name: Gemcitabine Hydrochloride 
CAS: 122111-03-9 
An Anticancer Agent
API USP Standard, High Quality, Commercial Production

Chemical Name Gemcitabine Hydrochloride
Synonyms Gemcitabine HCl; 2′-Deoxy-2′,2′-difluorocytidine; dFdC
CAS Number 122111-03-9
CAT Number RF-API41
Stock Status In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula C9H12ClF2N3O4
Molecular Weight 299.66
Brand Ruifu Chemical
Item Specifications
Appearance White Crystal Powder, Odorless
Solubility Soluble in Water, slightly soluble in methanol, practically insoluble in acetone
Identifiaction IR IR spectrum should be concordant to that of the reference standard
Identifiaction Chloride Positive. It meets the requirements of the tests for chloride
Appearance of Solution Solution S in clear and not more intensely colored than reference solution BY7
pH 2.0~3.0
Specific Rotation +43.0° ~ +50.0°
Heavy Metals (Pb) ≤10ppm
Loss on Drying ≤1.0%
Residue on Ignition ≤0.10%
Related Substances   
Cytosine ≤0.10%
α-Isomer ≤0.10%
Any Other Impurity ≤0.10%
Total Impurities ≤0.20%
Methanol ≤0.30%
Toluene ≤0.01%
Dichloromethane ≤0.01%
Acetone ≤0.50%
Assay 98.0%~102.0% (Calculated on dried base) 
Test Standard United States Pharmacopeia (USP) Standard
Usage Active Pharmaceutical Ingredient (API)

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

1
2

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of Gemcitabine Hydrochloride (CAS: 122111-03-9) with high quality API. 

Gemcitabine Hydrochloride (CAS: 122111-03-9) is a clinically useful anticancer agent.1 It exerts its cytotoxic effects via the metabolites gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP). dFdCTP is an inhibitor of DNA polymerase and is also incorporated in DNA strands resulting in termination of chain elongation and apoptosis. dFdCDP is an inhibitor of ribonucleotide reductase which results in depletion of deoxyribonucleotides needed for DNA synthesis. Gemcitabine metabolites have also been reported to inhibit cytidine triphosphate synthetase (CTP synthetase)2 and deoxycytidylate deaminase (dCMP deaminase)3. Topoisomerase 1 has also been shown to be a target for gemcitabine. 

Gemcitabine Hydrochloride (CAS: 122111-03-9) is a synthetic novel difluoro nucleoside drug that is anti-metabolic and antineoplastic. It is researched and developed by the Eli Lilly and Company and approved to be listed in South Africa, Sweden, the Netherlands, Australia and other countries in 1995. The United States Food and Drug Administration ( referred FDA) approved it as the first-line therapy for the clinical treatment of non-small cell lung cancer and pancreatic cancer. Gemcitabine hydrochloride, as a pro-drug, is a good substrate for the acidification of deoxygenation of thymine kinase phosphorus in the cell, and under the action of the enzyme, it can be converted into the following metabolites: gemcitabine mono-phosphate (dFdCMP), gemcitabine diphosphate (dFdCDP) and gemcitabine triphosphate (dFdCTP), among which the latter two are the active products. 


Product detail pictures:

Special Price for Noscapine Hydrochloride Hydrate - Gemcitabine Hydrochloride CAS 122111-03-9 API USP Standard High Purity – Ruifu detail pictures


Related Product Guide:

Gaining client pleasure is our company's aim without end. We are going to make excellent efforts to create new and top-quality goods, meet your special requirements and provide you with pre-sale, on-sale and after-sale companies for Special Price for Noscapine Hydrochloride Hydrate - Gemcitabine Hydrochloride CAS 122111-03-9 API USP Standard High Purity – Ruifu , The product will supply to all over the world, such as: Pakistan, Argentina, Cape Town, Many kinds of different products are available for you to choose, you can do one-stop shopping here. And customized orders are acceptable. Real business is to get win-win situation, if possible, we would like to provide more support for customers. Welcome all nice buyers communicate details of products with us!!
  • This manufacturer can keep improving and perfecting products and service, it is in line with the rules of market competition, a competitive company.
    5 Stars By Alexandra from United States - 2017.02.18 15:54
    The company has a good reputation in this industry, and finally it tured out that choose them is a good choice.
    5 Stars By Amelia from Venezuela - 2017.09.28 18:29
    Write your message here and send it to us