SPhos CAS 657408-07-6 Purity >98.0% (HPLC) Factory High Quality
Ruifu Chemical is the leading manufacturer of 2-Dicyclohexylphosphino-2',6'-Dimethoxybiphenyl (SPhos) (CAS: 657408-07-6) with high quality. Ruifu Chemical can provide worldwide delivery, competitive price, excellent service.
Purchase SPhos or other products, please contact us by e-mail: alvin@ruifuchem.com
| Chemical Name | 2-Dicyclohexylphosphino-2',6'-Dimethoxybiphenyl |
| Synonyms | SPhos; Dicyclohexyl(2',6'-Dimethoxy-[1,1'-biphenyl]-2-yl)phosphine; 2-Dicyclohexylphosphino-2',6'-Dimethoxy-1,1'-Biphenyl |
| CAS Number | 657408-07-6 |
| Stock Status | In Stock, Commercial Production |
| Molecular Formula | C26H35O2P |
| Molecular Weight | 410.54 |
| Melting Point | 164.0~166.0℃ |
| Store Under Inert Gas | Store Under Inert Gas |
| Sensitive | Air Sensitive |
| Solubility | Insoluble in Water, and Soluble in Chloroform |
| Storage Temperature | Store Long-Term at 2-8℃ |
| Shipping Conditions | Ambient Temperatures |
| COA & MSDS | Available |
| Product Categories | Phosphine Ligand |
| Origin of Product | Shanghai, China |
| Brand | Ruifu Chemical |
| Item | Specifications |
| Appearance | White Powder |
| Purity / Analysis Method | >98.0% (HPLC) |
| Solvents | <0.50% |
| Infrared Spectrum | Conforms to Structure |
| NMR Spectrum | Conforms to Structure |
| Test Standard | Enterprise Standard |
Package: Bottle, Aluminium foil bag, 25kg/cardboard drum, or according to customer's requirement.
Storage Condition: Air Sensitive. Store under inert gas. Keep the container tightly closed and store in a cool, dry and well-ventilated warehouse. Keep away from sunshine; avoid fire and heat sources; avoid moisture. Store away from strong oxidizing agents.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
Hazard Symbols Xn - Harmful
Risk Codes 40 - Limited evidence of a carcinogenic effect
Safety Description S24/25 - Avoid contact with skin and eyes.
S36/37 - Wear suitable protective clothing and gloves.
WGK Germany 3
TSCA No
2-Dicyclohexylphosphino-2′,6′-Dimethoxybiphenyl (Synonyms: SPhos) (CAS: 657408-07-6) is an air-stable, electron-rich biaryl phosphine ligand developed by the Buchwald group to enhance the reactivity of palladium catalysis during cross-coupling reactions. SPhos is a ligand used in chemical reactions for its ability to stabilize metal centers and increase reaction rates. SPhos was first developed by Professor Stephen Buchwald at the Massachusetts Institute of Technology in 2002 and was quickly adopted by chemists worldwide for its versatility.
SPhos (CAS: 657408-07-6) has low toxicity in various cell lines and does not pose significant safety concerns in scientific experiments. However, it is essential to handle SPhos with care as it can react with air and moisture, leading to a degradation of its chemical properties.
SPhos (CAS: 657408-07-6) has broad applications in scientific experiments, with its ability to stabilize metal centers and increase reaction rates. SPhos is commonly used in cross-coupling reactions, where it can aid in the formation of carbon-carbon and carbon-heteroatom bonds. SPhos has also been used in the development of pharmaceuticals and agrochemicals.
SPhos (CAS: 657408-07-6) has been used extensively in various chemical reactions and has been incorporated into many catalytic systems. SPhos has shown great potential in the development of new pharmaceuticals, and its use in cross-coupling reactions is still being explored.
1. Ligand/palladium catalyst for general Suzuki-Miyaura cross-coupling reactions.
2. Ligand/palladium catalyst for the Suzuki-Miyaura coupling of aryltrifluoroborates with aryl chlorides.
3. Ligand/palladium catalyst for the Suzuki-Miyaura reaction of heteroaryl halides and heteroaryl boronic acids and esters.
4. Ligand/palladium catalyst for the Kumada-Corriu cross-coupling reaction.
5. Ligand/palladium catalyst for the borylation of aryl halides with pinacol borane.
6. Suzuki couplings involving amino acids. Synthesis of biaryl derivatives of 4-hydroxyphenyl glycine, tyrosine and tryptophan.
7. Synthesis of substituted adamantylzinc reagents using Mg-insertion in the presence of zinc chloride.
8. Highly efficient catalyst for the palladium-catalyzed Suzuki-Miyura reaction of heteroaryl halides and heteroaryl boronic acids and esters.
