Super Lowest Price 4-Acetamidophenol - Cholestyramine CAS 11041-12-6 USP Standard High Purity – Ruifu

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Super Lowest Price 4-Acetamidophenol - Cholestyramine CAS 11041-12-6 USP Standard High Purity – Ruifu Detail:

Supply with High Purity and Stable Quality
Chemical Name: Cholestyramine
Synonyms: Cholestyramine Resin; Colestyramine
CAS: 11041-12-6
Cholestyramine in the treatment of type Ⅱa hyperlipoproteinemia
API High Quality, Commercial Production

Chemical Name	Cholestyramine
Synonyms	Cholestyramine Resin; Colestyramine
CAS Number	11041-12-6
CAT Number	RF-API23
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C27H47N
Molecular Weight	385.66878
Brand	Ruifu Chemical

Item	Specifications
Appearance	White or Off-White Powder, Odorless or has a slightly amine-like odor, Hygroscopic
Identification	The infrared absorption spectrum of the sample should be consistent with the reference standard
pH	4.0~6.0
Dialyzable Quaternary Amine	Should meet the requirements
Chloride	13.0%~17.0% (Calculated on the dried basis)
Loss on Drying	≤12.0%
Residue on Ignition	≤0.10%
Heavy Metals	≤20ppm
Bacterial Count	≤1000 cfu/g
Yeast and Mold	≤100 cfu/g
Escherichia Coli	Should not be detected
Live Mite Test	Should not be detected
Purity	Calculated on the dried basis, each g exchanges 2.0g~2.4g of Sodium Taurocholate
Test Standard	United States Pharmacopeia (USP)
Usage	Active Pharmaceutical Ingredient (API)

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of Cholestyramine (CAS: 11041-12-6) with high quality, active pharmaceutical ingredient (API). Cholestyramine (Colestyramine) is a bile acid binding resin and can inhibit intestinal bile acid absorption which results in the increasing bile acid synthesis from cholesterol. A strongly basic anion exchange resin whose main constituent is polystyrene trimethylbenzylammonium Cl(-) anion.

Cholestyramine, is a strongly basic quaternary ammonium anion exchange resin, it is used in low-density lipoprotein hyperlipidemia that includesⅡa, Ⅱb hyperlipidemia,it is the strongest cholesterol-lowering drug. After oral administration, it is not absorbed, in the intestine the containing chlorine ion is exchanged with the bile acid, it can bind stably with bile acids until the feces, it can reduce the absorption of exogenous cholesterol, hinder the enterohepatic circulation of bile acids absorbed into blood, it can reduce the amount of bile acids in the blood, which prompt blood cholesterol conversion to bile acids, which lowers cholesterol. Cholestyramine has no lowering effect on triglycerides. Because of the powerful cholesterol-lowering effect, the product becomes the choice of drug for type Ⅱa hyperlipoproteinemia. It shall be used in combination with drugs which can reduce blood triglyceride such as clofibrate or nicotinic acid for the treatment of type Ⅱb hyperlipoproteinemia. For hyperlipoproteinemia Ⅲ, Ⅳ, Ⅴ, we should not use cholestyramine. In addition, the product can also be used for the treatment of skin itching caused by atherosclerosis and cirrhosis, cholelithiasis.

Cholestyramine: it is mainly used for the treatment of type Ⅱa hyperlipoproteinemia, especially in familial hypercholesterolemia. Also it is used for the treatment of primary biliary cirrhosis, drug-induced cholestatic jaundice itching, hypercholesterolemia, chronic cholecystitis, gallstones, Porphyrin thesaurismosis. Treatment of Atherosclerosis: 4~5g, 3 times/d. Itching: Start amount of 6~10g/d, maintenance dose of 3g/d, administration for 3 times. Long-term use can reduce intestinal binding bile salt, and cause fat malabsorption, long-term use should add vitamin A, D, K and other fat-soluble vitamins and calcium appropriately, gastrointestinal responders may be appropriate with stomach medication.

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