Super Purchasing for Etravirine - Abacavir Sulfate CAS 188062-50-2 API High Purity anti-HIV – Ruifu

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Super Purchasing for Etravirine - Abacavir Sulfate CAS 188062-50-2 API High Purity anti-HIV – Ruifu Detail:

Manufacturer Supply with High Purity and Stable Quality
Chemical Name: Abacavir Sulfate
CAS: 188062-50-2
Abacavir Sulfate is a nucleoside reverse transcriptase inhibitor that works against replication of a variety of HIV-1 and HIV-2 strains.
API High Quality, Commercial Production

Chemical Name	Abacavir Sulfate
CAS Number	188062-50-2
CAT Number	RF-API63
Stock Status	In Stock, Production Scale Up to Hundreds of Kilograms
Molecular Formula	C28H38N12O6S
Molecular Weight	670.74
Brand	Ruifu Chemical

Item	Specifications
Appearance	White to Off-White Solid
Identification	IR/HPLC
Assay	≥98.0% (HPLC)
Melting Point	>205°C (dec.)
Loss on Drying	≤0.50%
Residue on Ignition	≤0.50%
Heavy Metals	≤20ppm
Test Standard	Enterprise Standard
Usage	Active Pharmaceutical Ingredient (API); anti-HIV

Package: Bottle, Aluminum foil bag, Cardboard drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Abacavir Sulfate is a nucleoside reverse transcriptase inhibitor that works against replication of a variety of HIV-1 and HIV-2 strains, inhibits HIV replication. Orally active and brain penetrant. Antiretroviral agent. Abacavir sulfate was first launched as Ziagen in the US for the treatment of human immunodeficiency virus (HIV) infection, in combination with other antiretroviral drugs. Abacavir is a carbocyclic nucleoside reverse transcriptase inhibitor (nRTI); it is one of the most potent anti-HIV agents to date. The compound can be prepared by an enantioselective synthesis involving palladium-catalyzed coupling of a chloropurine with a carbocyclic allylic diacetate. In vitro, Abacavir is a potent and selective inhibitor of HIV-1 and HIV-2 replication. Resistance to Abacavir develops more slowly than for other anti-HIV agents. Abacavir is highly synergistic with protease inhibitors such as Amprenavir. In clinical trials for HIV infections in adults, it produced durable suppression in viral load. Combinations with different protease inhibitors such as Nelfinavir, Saquinavir or Indinavir markedly reduced plasma viral load to undetectable levels for at least 48 weeks, and significantly raised CD4+ cell counts in adults with HIV infection, especially nRTI-naive patients. Abacavir has a good oral availability and its penetration into CSF is much more significant than for other anti-HIV drugs. The two major metabolites identified in humans were the 5′-carboxylate and the 5′-glucuronide, mainly excreted via the renal route.

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