Trametinib (DMSO Solvate) CAS 1187431-43-1 Purity >98.0% (HPLC)
Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer of Trametinib (DMSO Solvate) (GSK-1120212 (DMSO Solvate)) (CAS: 1187431-43-1) with high quality. It is a powerful and selective MEK1/MEK2 inhibitor. It is an approved and new targeted drug for the treatment of melanoma.
Ruifu Chemical has been supplying pharmaceutical intermediates and APIs, fine chemicals more than 15 years.
Ruifu Chemical can provide worldwide delivery, competitive price, excellent service.
Purchase Trametinib (DMSO Solvate) or other products, please contact us by e-mail: alvin@ruifuchem.com
| Chemical Name | Trametinib (DMSO Solvate) |
| Synonyms | Trametinib DMSO (API); GSK-1120212 (DMSO Solvate); JTP-74057 (DMSO Solvate); Trametinib Dimethyl Sulfoxide; GSK-1120212 Dimethyl Sulfoxide; N-(3-(3-Cyclopropyl-5-((2-Fluoro-4-Iodophenyl)amino)-6,8-Dimethyl-2,4,7-Trioxo-3,4,6,7-Tetrahydropyrido[4,3-d]pyrimidin-1(2H)-yl)phenyl)acetamide Dimethyl Sulfoxide Complex |
| Stock Status | In Stock |
| CAS Number | 1187431-43-1 |
| Related CAS | 871700-17-3 |
| Molecular Formula | C28H29FIN5O5S |
| Molecular Weight | 693.53 g/mol |
| Solubility | Soluble in DMSO, Insoluble in Water |
| Storage Temperature | Store Long-Term at 2-8℃ |
| Shipping Condition | Shipped Under Ambient Temperature For Short Term |
| Shelf Life | >2 Years If Stored Properly |
| COA & MSDS | Available |
| Origin of Product | Shanghai, China |
| Product Categories |
API (Active Pharmaceutical Ingredient) |
| Caution | Not For Human or Veterinary Use. For Research Use Only. |
| Brand | Ruifu Chemical |
| Items | Specifications | Results |
| Appearance | White Solid | White Solid |
| Loss on Drying | <0.50% | Conforms |
| Purity / Analysis Method | >98.0% (HPLC) | 99.2% |
| 1H NMR Spectrum | Consistent with Structure | Conforms |
| LC-MS | Consistent with Structure | Conforms |
| Conclusion | The product has been tested and complies with the given specifications | |
Package: Bottle, or according to customer's requirement.
Storage Condition: Keep the container tightly closed. Store in a cool, dry (2~8℃) and well-ventilated warehouse away from incompatible substances. Keep away from sunshine; avoid fire and heat sources; avoid moisture.
Shipping: Deliver to worldwide by air, by FedEx / DHL Express. Provide fast and reliable delivery.
How to Purchase? Please contact Dr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Years Experience? We have more than 15 years of experience in the manufacture and export of a wide range of high quality pharmaceutical intermediates or fine chemicals.
Main Markets? Sell to domestic market, North America, Europe, India, Korea, Japanese, Australia, etc.
Advantages? Superior quality, affordable price, professional services and technical support, fast delivery.
Quality Assurance? Strict quality control system. Professional equipment for analysis include NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, K.F, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, etc.
Samples? Most products provide free samples for quality evaluation, shipping cost should be paid by customers.
Factory Audit? Factory audit welcome. Please make an appointment in advance.
MOQ? No MOQ. Small order is acceptable.
Delivery Time? If within stock, three days delivery guaranteed.
Transportation? By Express (FedEx, DHL), by Air, by Sea.
Documents? After sales service: COA, MOA, ROS, MSDS, etc. can be provided.
Custom Synthesis? Can provide custom synthesis services to best fit your research needs.
Payment Terms? Proforma invoice will be sent first after confirmation of order, enclosed our bank information. Payment by T/T (Telex Transfer), PayPal, Western Union, etc.
Trametinib (DMSO Solvate) (GSK-1120212 (DMSO Solvate)) (CAS: 1187431-43-1) is a solvated form of trametinib at 1:1 molar ratio of trametinib to dimethyl sulfoxide. Trametinib, is an approved and new targeted drug for the treatment of melanoma. It is a powerful and selective MEK1/MEK2 inhibitor which can effectively prevent cancer cell proliferating and can induce cell apoptosis, and increase the life of patients.
Trametinib is a reversible, highly selective, allosteric inhibitor of mitogen-activated extracellular signal regulated kinase 1 (MEK1) and MEK2 activation and kinase activity. MEK proteins are components of the extracellular signal-related kinase (ERK) pathway. In melanoma and other cancers, this pathway is often activated by mutated forms of BRAF which activates MEK. Trametinib inhibits activation of MEK by BRAF and inhibits MEK kinase activity. Trametinib inhibits growth of BRAF V600 mutant melanoma cell lines and demonstrates anti-tumor effects in BRAF V600 mutant melanoma animal models.
Trametinib is indicated as monotherapy or in combination with Tafinlar (dabrafenib) for the treatment of adult patients with unresectable or metastatic melanoma with a BRAF V600 mutation.
Not For Human or Veterinary Use. For Research Use Only.
