Wholesale Discount 1-β-D-Arabinofuranosyluracil - 3-Benzyl-6-Bromo-2-Chloroquinoline CAS 654655-68-2 Bedaquiline Fumarate Intermediate – Ruifu

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Wholesale Discount 1-β-D-Arabinofuranosyluracil - 3-Benzyl-6-Bromo-2-Chloroquinoline CAS 654655-68-2 Bedaquiline Fumarate Intermediate – Ruifu Detail:

Commercial Supply Bedaquiline Related Intermediates:
3-Benzyl-6-Bbromo-2-Mmethoxyquinoline CAS: 654655-69-3
3-Benzyl-6-Bromo-2-Chloroquinoline CAS: 654655-68-2
3-(Dimethylamino)-1-(Naphthalen-1-yl)propan-1-one Hydrochloride CAS: 5409-58-5
Bedaquiline CAS: 843663-66-1
Bedaquiline Fumarate CAS: 845533-86-0

Chemical Name	3-Benzyl-6-Bromo-2-Chloroquinoline
Synonyms	6-Bromo-2-Chloro-3-(Phenylmethyl)quinoline; Bedaquiline Impurity B; Bedaquiline Fumarate Impurity 5
CAS Number	654655-68-2
CAT Number	RF-PI107
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C₁₆H₁₁BrClN
Molecular Weight	332.62
Brand	Ruifu Chemical

Item	Specifications
Appearance	White to Off-White or Light Yellow Powder
Purity / Analysis Method	≥99.0% (HPLC)
Melting Point	100.0~120.0℃
Moisture (K.F)	≤0.50%
Residue on ignition	≤0.50%
Test Standard	Enterprise Standard
Usage	Bedaquiline Fumarate (CAS: 845533-86-0) Intermediate

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3-Benzyl-6-bromo-2-chloroquinoline CAS: 654655-68-2 is a main intermediate of Bedaquiline.
Bedaquiline Fumarate is a diarylquinone drug developed by Janssen Pharmaceutical. The drug, which was approved in 2012 for the treatment of multidrug-resistant tuberculosis (MDR-TB), was developed in partnership with Johnson & Johnson and represents the first new tuberculosis therapy approved in over four decades. Bedaquiline is the first member of a new class of diarylquinone compounds whose mechanism of action inhibits Mycobaterium tuberculosis ATP synthase which deprives bacterium of energy.
Bedaquiline Fumarate used in combination therapy for the treatment of pulmonary multi-drug resistant tuberculosis by inhibition of ATP synthase, an enzyme essential for the replication of th mycobacteria.

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