Wholesale Price China R-Styrene Oxide - (R)-(-)-3-Quinuclidinol CAS 25333-42-0 Purity ≥99.0% Chiral Purity ≥99.0% Solifenacin Succinate Intermediate – Ruifu

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Wholesale Price China R-Styrene Oxide - (R)-(-)-3-Quinuclidinol CAS 25333-42-0 Purity ≥99.0% Chiral Purity ≥99.0% Solifenacin Succinate Intermediate – Ruifu Detail:

Chemical Name	(R)-(-)-3-Quinuclidinol
Synonyms	(R)-3-Quinuclinol; Solifenacin Succinate Intermediate C
CAS Number	25333-42-0
CAT Number	RF-CC117
Stock Status	In Stock, Production Scale Up to Tons
Molecular Formula	C7H13NO
Molecular Weight	127.18
Brand	Ruifu Chemical

Item	Specifications
Appearance	White or Off-White Powder
Identification RT (by GC)	Conform with the Reference Standard
Melting Point	212.0~224.0℃
Specific Rotation [α]_D²⁰	-40.0°~ -48.0°
Moisture (K.F)	≤0.5%
Residue on Ignition	≤0.5%
Purity	≥99.0%
Total Impurities	≤1.0%
Chiral Purity	≥99.0%
Enantiomer	≤1.0%
Assay	98.0%～101.0%（on anhydrous basis）
Test Standard	Enterprise Standard
Usage	Chiral Compounds; Pharmaceutical Intermediates

Package: Bottle, Aluminium foil bag, Cardboard Drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of (R)-(-)-3-Quinuclidinol (CAS: 25333-42-0) with high quality, widely used in organic synthesis, synthesis of pharmaceutical intermediates and Active Pharmaceutical Ingredient (API) synthesis.

(R)-(-)-3-Quinuclidinol (CAS: 25333-42-0) can be used as an intermediate in the synthesis of Solifenacin Succinate (CAS: 242478-38-2)

Solifenacin Succinate (CAS: 242478-38-2) is an antimuscarinic medication that is used to treat an overactive bladder causing symptoms of frequency, urgency, or incontinence.

Solifenacin Succinate (CAS: 242478-38-2) is an M3 muscarinic receptor antagonist that was developed and launched for the treatment of overactive bladder (pollakiuria) in Europe. M3 receptors have been implicated in neurally evoked smooth muscle contractions of the bladder, and M2 receptors have also been suspected of playing a role because of their dominance in the detrusor muscle. Solifenacin displays affinity for both M3 and M2 receptors with Ki values of 9.9nM and 120 nM, respectively. Since muscarinic salivary glands are of the M3 persuasion, a common side effect of antimuscarinic therapy is dry mouth. At the cellular level, solifenacin possesses a selective preference for bladder over salivary gland that is 15-fold greater than that of atropine suggesting a lower probability of inducing dry mouth at pharmacologically relevant doses. The synthesis of solifenacin involves the preparation of racemic 1-phenyl- 1,2,3,4-tetrahydroisoquinoline via cyclization of N-(2-phenylethyl)benzamide, and subsequent reaction with ethyl chloroformate and transesterification with (R)- 3-quinuclidinol. Chiral chromatography affords the isolation of the desired diastereomer. Alternatively, 1-phenyl-1,2,3,4-tetrahydroisoquinoline may be subjected to optical resolution with (+)-tartaric acid prior to treatment with ethyl chloroformate and subsequent transesterification.

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