Wholesale (R)-(-)-alpha-Methoxyphenylacetic acid - (S)-(+)-3-Quinuclidinol CAS 34583-34-1 Solifenacin Succinate Intermediate High Quality – Ruifu

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Wholesale (R)-(-)-alpha-Methoxyphenylacetic acid - (S)-(+)-3-Quinuclidinol CAS 34583-34-1 Solifenacin Succinate Intermediate High Quality – Ruifu Detail:

Manufacturer with High Quality and Competitive Price
Commercial Supply Solifenacin Succinate (CAS: 242478-38-2) Related Intermediates:
Solifenacin Succinate CAS: 242478-38-2
(R)-(-)-3-Quinuclidinol CAS: 25333-42-0
(S)-(+)-3-Quinuclidinol CAS: 34583-34-1
3-Quinuclidinone Hydrochloride CAS: 1193-65-3
(R)-3-Quinuclidinol Hydrochloride CAS: 42437-96-7
1-Phenyl-1,2,3,4-Tetrahydro-Isoquinoline CAS: 22990-19-8
(S)-1-Phenyl-1,2,3,4-Tetrahydroisoquinoline CAS: 118864-75-8

Chemical Name (S)-(+)-3-Quinuclidinol
Synonyms (S)-Quinuclidin-3-ol; Solifenacin Succinate Intermediate B
CAS Number 34583-34-1
CAT Number RF-CC118
Stock Status In Stock, Production Scale Up to Tons
Molecular Formula C7H13NO
Molecular Weight 127.18
Brand Ruifu Chemical
Item Specifications
Appearance Off-White to White Crystalline Powder
Identification IR Specturm Conforms to Reference Spectrum
Specific Rotation [α]D20 44.0°±2.0°
Loss On Drying ≤0.50%
Purity ≥99.0%
Assay 98.0%~102.0% (on anhydrous basis)
Test Standard Enterprise Standard
Usage Chiral Compounds; Pharmaceutical Intermediates

Package: Bottle, Aluminium foil bag, Cardboard Drum, 25kg/Drum, or according to customer’s requirement.

Storage Condition: Store in sealed containers at cool and dry place; Protect from light, moisture and pest infestation.

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Shanghai Ruifu Chemical Co., Ltd. is the leading manufacturer and supplier of (S)-(+)-3-Quinuclidinol (CAS: 34583-34-1) with high quality, widely used in synthesis of pharmaceutical intermediates and active pharmaceutical ingredient (API). (S)-(+)-3-Quinuclidinol is an intermediate in the synthesis of Solifenacin Succinate (CAS: 242478-38-2).  

Solifenacin Succinate (CAS: 242478-38-2) is an antimuscarinic medication that is used to treat an overactive bladder causing symptoms of frequency, urgency, or incontinence. Solifenacin Succinate is an M3 muscarinic receptor antagonist that was developed and launched for the treatment of overactive bladder (pollakiuria) in Europe. M3 receptors have been implicated in neurally evoked smooth muscle contractions of the bladder, and M2 receptors have also been suspected of playing a role because of their dominance in the detrusor muscle. Solifenacin displays affinity for both M3 and M2 receptors with Ki values of 9.9nM and 120 nM, respectively. Since muscarinic salivary glands are of the M3 persuasion, a common side effect of antimuscarinic therapy is dry mouth. At the cellular level, solifenacin possesses a selective preference for bladder over salivary gland that is 15-fold greater than that of atropine suggesting a lower probability of inducing dry mouth at pharmacologically relevant doses. The synthesis of solifenacin involves the preparation of racemic 1-phenyl- 1,2,3,4-tetrahydroisoquinoline via cyclization of N-(2-phenylethyl)benzamide, and subsequent reaction with ethyl chloroformate and transesterification with (R)- 3-quinuclidinol. Chiral chromatography affords the isolation of the desired diastereomer. Alternatively, 1-phenyl-1,2,3,4-tetrahydroisoquinoline may be subjected to optical resolution with (+)-tartaric acid prior to treatment with ethyl chloroformate and subsequent transesterification.  


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Persisting in "High quality, Prompt Delivery, Aggressive Price", we have established long-term cooperation with clientele from both equally overseas and domestically and get new and old clients' higher comments for Wholesale (R)-(-)-alpha-Methoxyphenylacetic acid - (S)-(+)-3-Quinuclidinol CAS 34583-34-1 Solifenacin Succinate Intermediate High Quality – Ruifu , The product will supply to all over the world, such as: Guatemala, Sri Lanka, Sudan, Our company is working by the operation principle of "integrity-based, cooperation created, people oriented, win-win cooperation". We hope we can have a friendly relationship with businessman from all over the world
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